Distinct Chk2 activation pathways are triggered by genistein and DNA-damaging agents in human melanoma cells.Examination of Chk2 protein revealed a decreased expression of Chk2 protein in cisplatin -resistant ovarian cancer cell lines, suggesting that degradation or decreased expression of Chk2 is partially responsible for chemo-resistance.We identified three serine residues ( S19, S33, and S35) on Chk2 that became phosphorylated in vivo rapidly and exclusively in response to ionizing radiation (IR)- induced DNA double-strand breaks in an ATM - and Nbs1 -dependent but ataxia telangiectasia- and Rad3-related-independent manner.Chemical compound and disease context of CHEK2
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